Humanized recombinant vaccinia virus complement control protein (hrVCP) with three amino acid changes, H98Y, E102K, and E120K creating an additional putative heparin binding site, is 100-fold more active than rVCP in blocking both classical and alternative complement pathways

Yohannes T. Ghebremariam, Odutayo O. Odunuga, Kristen Janse, Girish J. Kotwal

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalAnnals of the New York Academy of Sciences
StatePublished - 2005
Externally publishedYes

ASJC Scopus Subject Areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


  • 100-Fold potency
  • Complement
  • Heparin
  • Humanized rVCPs
  • Site-directed mutagenesis
  • rVCP

Cite this